The kainic acid model of temporal lobe epilepsy
نویسندگان
چکیده
منابع مشابه
The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat
Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effe...
متن کاملthe protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat
background and objective: temporal lobe epilepsy (tle) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. this study was designed to assess the protective effe...
متن کاملantiepileptic effect of vitamin e on kainic acid-induced temporal lobe epilepsy in rats
background epilepsy is a chronic neurological disease with the prevalence of around one percent. despite the introductions of several anti-epileptic drugs, around 1/3 of epileptic patients are resistant to the anti-epileptic medications. objectives considering the evidence regarding the anti-oxidant action of vitamin e and its beneficiary effect in the treatment of epilepsy, we investigated the...
متن کاملResting state functional network disruptions in a kainic acid model of temporal lobe epilepsy
We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed ...
متن کاملA Macaque Model of Mesial Temporal Lobe Epilepsy Induced by Unilateral Intrahippocampal Injection of Kainic Acid
OBJECTIVE In order to better investigate the cause/effect relationships of human mesial temporal lobe epilepsy (mTLE), we hereby describe a new non-human primate model of mTLE. METHODS Ten macaques were studied and divided into 2 groups: saline control group (n = 4) and kainic acid (KA) injection group (n = 6). All macaques were implanted bilaterally with subdural electrodes over temporal cor...
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ژورنال
عنوان ژورنال: Neuroscience & Biobehavioral Reviews
سال: 2013
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2013.10.011